Sphinx: a secure architecture based on binary code diversification and execution obfuscation

Sphinx, a hardware-software co-design architecture for binary code and runtime obfuscation. The Sphinx architecture uses binary code diversification and self-reconfigurable processing elements to maintain application functionality while obfuscating the binary code and architecture states to attackers. This approach dramatically reduces an attacker’s ability to exploit information gained from one deployment to attack another deployment. Our results show that the Sphinx is able to decouple the program’s execution time, power and memory and I/O activities from its functionality. It is also practical in the sense that the system (both software and hardware) overheads are minimal.Published versio

Sphinx: A Secure Architecture Based on Binary Code Diversification and Execution Obfuscation

Sphinx, a hardware-software co-design architecture for binary code and runtime obfuscation. The Sphinx architecture uses binary code diversification and self-reconfigurable processing elements to maintain application functionality while obfuscating the binary code and architecture states to attackers. This approach dramatically reduces an attacker's ability to exploit information gained from one deployment to attack another deployment. Our results show that the Sphinx is able to decouple the program's execution time, power and memory and I/O activities from its functionality. It is also practical in the sense that the system (both software and hardware) overheads are minimal.Comment: Boston Area Architecture 2018 Workshop (BARC18

BRISC-V: An Open-Source Architecture Design Space Exploration Toolbox

In this work, we introduce a platform for register-transfer level (RTL) architecture design space exploration. The platform is an open-source, parameterized, synthesizable set of RTL modules for designing RISC-V based single and multi-core architecture systems. The platform is designed with a high degree of modularity. It provides highly-parameterized, composable RTL modules for fast and accurate exploration of different RISC-V based core complexities, multi-level caching and memory organizations, system topologies, router architectures, and routing schemes. The platform can be used for both RTL simulation and FPGA based emulation. The hardware modules are implemented in synthesizable Verilog using no vendor-specific blocks. The platform includes a RISC-V compiler toolchain to assist in developing software for the cores, a web-based system configuration graphical user interface (GUI) and a web-based RISC-V assembly simulator. The platform supports a myriad of RISC-V architectures, ranging from a simple single cycle processor to a multi-core SoC with a complex memory hierarchy and a network-on-chip. The modules are designed to support incremental additions and modifications. The interfaces between components are particularly designed to allow parts of the processor such as whole cache modules, cores or individual pipeline stages, to be modified or replaced without impacting the rest of the system. The platform allows researchers to quickly instantiate complete working RISC-V multi-core systems with synthesizable RTL and make targeted modifications to fit their needs. The complete platform (including Verilog source code) can be downloaded at https://ascslab.org/research/briscv/explorer/explorer.html.Comment: In Proceedings of the 2019 ACM/SIGDA International Symposium on Field-Programmable Gate Arrays (FPGA '19

Latent Heat Flux Profiles from Collocated Airborne Water Vapor and Wind Lidars during IHOP_2002

Latent heat flux profiles in the convective boundary layer (CBL) are obtained for the first time with the combination of the DLR water vapor differential absorption lidar (DIAL) and the NOAA high resolution Doppler wind lidar (HRDL). Both instruments were integrated nadir viewing on board the DLR “Falcon” research aircraft during the International H2O Project (IHOP_2002) over the U.S. Southern Great Plains. Flux profiles from 300 – 2500 m AGL are computed from high spatial resolution (150 m horizontal and vertical) two-dimensional water vapor and vertical velocity lidar cross sections using the eddy covariance technique. All cospectra show significant contributions to the flux between 1 and 10 km wavelength, with peaks between 2 and 6 km, originating from large eddies. The main flux uncertainty is due to low sampling (55 % rmse at mid-CBL), while instrument noise (15 %) and systematic errors (7 %) play a minor role. The combination of a water vapor and a wind lidar on an aircraft appears as an attractive new tool that allows measuring latent heat flux profiles from a single over-flight of the investigated area

Five Blood Pressure Loci Identified by an Updated Genome-Wide Linkage Scan: Meta-Analysis of the Family Blood Pressure Program

Background A preliminary genome-wide linkage analysis of blood pressure in the Family Blood Pressure Program (FBPP) was reported previously. We harnessed the power and ethnic diversity of the final pooled FBPP dataset to identify novel loci for blood pressure thereby enhancing localization of genes containing less common variants with large effects on blood pressure levels and hypertension. Methods We performed one overall and 4 race-specific meta-analyses of genome-wide blood pressure linkage scans using data on 4,226African-American, 2,154 Asian, 4,229 Caucasian, and 2,435 Mexican- American participants (total N = 13,044). Variance components models were fit to measured (raw) blood pressure levels and two types of antihypertensive medication adjusted blood pressure phenotypes within each of 10 subgroups defined by race and network. A modified Fisher's method was used to combine the P values for each linkage marker across the 10 subgroups. Results Five quantitative trait loci (QTLs) were detected on chromosomes 6p22.3, 8q23.1, 20q13.12, 21q21.1, and 21q21.3 based on significant linkage evidence (defined by logarithm of odds (lod) score ≥3) in at least one meta-analysis and lod scores ≥1 in at least 2 subgroups defined by network and race. The chromosome 8q23.1 locus was supported by Asian-, Caucasian-, and Mexican-American-specific meta-analyses. Conclusions The new QTLs reported justify new candidate gene studies. They may help support results from genome-wide association studies (GWAS) that fall in these QTL regions but fail to achieve the genome-wide significance. American Journal of Hypertension advance online publication 9 December 2010;doi:10.1038/ajh.2010.23

Positional identification of variants of Adamts16 linked to inherited hypertension

A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two genes, LOC306664 and LOC306665. LOC306664 is predicted to translate into A Disintegrin-like and Metalloproteinase with Thrombospondin Motifs-16 (Adamts16). LOC306665 is a novel gene. All predicted exons of both LOC306664 and LOC306665 were sequenced. Non-synonymous variants were identified in only one of these genes, LOC306664. These variants were naturally existing polymorphisms among inbred, outbred and wild rats. The full-length rat transcript of Adamts16 was detected in multiple tissues. Similar to ADAMTS16 in humans, expression of Adamts16 was prominent in the kidney. Renal transcriptome analysis suggested that a network of genes related to BP was differential between congenic and S rats. These genes were also differentially expressed between kidney cell lines with or without knock-down of Adamts16. Adamts16 is conserved between rats and humans. It is a candidate gene within the homologous region on human Chromosome 5, which is linked to systolic and diastolic BP in the Quebec Family Study. Multiple variants, including an Ala to Pro variant in codon 90 (rs2086310) of human ADAMTS16, were associated with human resting systolic BP (SBP). Replication study in GenNet confirmed the association of two variants of ADAMTS16 with SBP, including rs2086310. Overall, our report represents a high resolution positional cloning and translational study for Adamts16 as a candidate gene controlling B